maguire lab
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Recent Publications

Melón L, Hammond R, Lewis M, Maguire J. A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression. Frontiers in Endocrinol. 2018; 9: 703.

Melón L, Hooper A, Yang X, Moss S, Maguire J.  Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.  Psychoneuroendocrinology.  2017. 90: 182-193.

Hooper A, Paracha R, Maguire J.  Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.  Epilepsy & Behavior. 2017. 78:124-133.  

Davis P, Zaki Y, Maguire J, Reijmers L.  Cellular and oscillatory substrates of fear extinction learning. Nature Neuroscience. 2017. 20(11):1624-1633. PMID: 28967909.




Sivakumaran S, Maguire J. Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. Epilepsia. 2016 Feb;57(2):222-32. doi: 10.1111/epi.13270. PubMed PMID: 26659482.

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci. 2015 May 27;35(21):8291-6. doi: 10.1523/JNEUROSCI.5205-14.2015. PubMed PMID: 26019342; PubMed Central PMCID: PMC4444547.

O'Toole KK, Hooper A, Wakefield S, Maguire J. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 2014 Jan;108(1):29-43. doi: 10.1016/j.eplepsyres.2013.10.013. PubMed PMID: 24225328; PubMed Central PMCID: PMC3872265.

Lee V, Maguire J. Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 2013 Dec;110(11):2520-35. doi: 10.1152/jn.00047.2013. PubMed PMID: 24027099; PubMed Central PMCID: PMC3882765.


Postpartum Depression

Maguire J, Mody I. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plast. 2016;2016:2762518. doi: 10.1155/2016/2762518. PubMed PMID: 26819762; PubMed Central PMCID: PMC4706939.

Maguire J, Ferando I, Simonsen C, Mody I. Excitability changes related to GABAA receptor plasticity during pregnancy. J Neurosci. 2009 Jul 29;29(30):9592-601. doi: 10.1523/JNEUROSCI.2162-09.2009. PubMed PMID: 19641122; PubMed Central PMCID: PMC2875247.

Maguire J, Mody I. Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci. 2007 Feb 28;27(9):2155-62. PubMed PMID: 17329412.

Maguire JL, Stell BM, Rafizadeh M, Mody I. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci. 2005 Jun;8(6):797-804. PubMed PMID: 15895085.



Lee V, MacKenzie G, Hooper A, Maguire J. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus. 2016 Oct;26(10):1276-90. doi: 10.1002/hipo.22604. PubMed PMID: 27163381; PubMed Central PMCID: PMC5030140.

Hooper A, Maguire J. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus. 2016 Jan;26(1):41-53. doi: 10.1002/hipo.22487. PubMed PMID: 26135556.

MacKenzie G, Maguire J. Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res. 2015 Jan;109:13-27. doi: 10.1016/j.eplepsyres.2014.10.003. PubMed PMID: 25524838; PubMed Central PMCID: PMC4272449.

Lee V, Sarkar J, Maguire J. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology. 2014 Mar;41:75-88. doi: 10.1016/j.psyneuen.2013.12.011. PubMed PMID: 24495609; PubMed Central PMCID: PMC3947777.

Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 2011 Dec 14;31(50):18198-210. doi: 10.1523/JNEUROSCI.2560-11.2011. PubMed PMID: 22171026; PubMed Central PMCID: PMC3272883.

Alcohol Use Disorders

Darnieder LM, Melón LC, Do T, Walton NL, Miczek KA, Maguire JL. Female-specific decreases in alcohol binge-like drinking resulting from GABA A receptor delta-subunit knockdown in the VTA. Scientific reports 9 (1), 8102.

Melón L, Nasman J, St. John A, Mbonu K, Maguire J. Interneuronal δ-GABAA receptors regulate binge drinking and are necessary for the behavioral effects of early withdrawal. 2019. Neuropsychopharmacology.  44: 425–434