publications

full list of publications on Google Scholar: click here

Recent Publications

Maguire J & Mennerick S (2024) Neurosteroids: mechanistic considerations and clinical prospects. Neuropsychopharmacology. volume 49, pages73–82.

Pantelis Antonoudiou, Bradly Stone, Phillip L.W. Colmers, Aidan Evans-Strong, Najah Walton, Grant Weiss, Jamie Maguire (2023) Experience-dependent information routing through the basolateral amygdala. bioRxiv. https://doi.org/10.1101/2023.08.02.551710.

Bradly T. Stone, Pantelis Antonoudiou, Eric Teboul, Garrett Scarpa, Grant Weiss, Jamie L. Maguire (2023) Early life stress impairs VTA coordination of BLA network and behavioral states. bioRxiv. https://doi.org/10.1101/2023.09.16.558081.

Kenneth A. Amaya, Eric Teboul, Grant L. Weiss, Pantelis Antonoudiou, Jamie L. Maguire (2023) Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors. bioRxiv. https://doi.org/10.1101/2023.08.09.552674.

Aidan Evans-Strong, Najah Walton, Abby Roper, S. Tiffany Donaldson, Mike Lewis, Jamie Maguire (2023) Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis. bioRxiv. https://doi.org/10.1101/2023.07.04.547710.

Walton N., Antonoudiou P., Barros L., DiLeo A., Gabby J., Howard S., Paracha R., Sanchez E., Weiss G., Kong D., Maguire J (2023) Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2023.01.022.

Kirstie Cumming and Jamie Maguire (2022) Interneurons direct circuit-specific flow of information to communicate stressful experiences. Neuron. Volume 110, Issue 6, 911-913.

Epilepsy

Hooper A, Paracha R, Maguire J.  Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.  Epilepsy & Behavior. 2017. 78:124-133.  

Sivakumaran S, Maguire J. Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. Epilepsia. 2016 Feb;57(2):222-32. doi: 10.1111/epi.13270. PubMed PMID: 26659482.

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci. 2015 May 27;35(21):8291-6. doi: 10.1523/JNEUROSCI.5205-14.2015. PubMed PMID: 26019342; PubMed Central PMCID: PMC4444547.

O'Toole KK, Hooper A, Wakefield S, Maguire J. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 2014 Jan;108(1):29-43. doi: 10.1016/j.eplepsyres.2013.10.013. PubMed PMID: 24225328; PubMed Central PMCID: PMC3872265.

Lee V, Maguire J. Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 2013 Dec;110(11):2520-35. doi: 10.1152/jn.00047.2013. PubMed PMID: 24027099; PubMed Central PMCID: PMC3882765.

Depression/ Postpartum Depression

Antonoudiou P., Colmers P., Walton N., Weiss G., Smith A., Nguyen D, Lewis M., Quirk M., Barros L., Melon L., Maguire J. (2021) Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala. Biological Psychiatry. Feb 1;91(3):283-293. https://doi.org/10.1016/j.biopsych.2021.07.017.

Melón L, Hammond R, Lewis M, Maguire J. A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression. Frontiers in Endocrinol. 2018; 9: 703.

Melón L, Hooper A, Yang X, Moss S, Maguire J.  Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.  Psychoneuroendocrinology.  2017. 90: 182-193.

Maguire J, Mody I. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plast. 2016;2016:2762518. doi: 10.1155/2016/2762518. PubMed PMID: 26819762; PubMed Central PMCID: PMC4706939.

Maguire J, Ferando I, Simonsen C, Mody I. Excitability changes related to GABAA receptor plasticity during pregnancy. J Neurosci. 2009 Jul 29;29(30):9592-601. doi: 10.1523/JNEUROSCI.2162-09.2009. PubMed PMID: 19641122; PubMed Central PMCID: PMC2875247.

Maguire J, Mody I. Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci. 2007 Feb 28;27(9):2155-62. PubMed PMID: 17329412.

Maguire JL, Stell BM, Rafizadeh M, Mody I. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci. 2005 Jun;8(6):797-804. PubMed PMID: 15895085.

Stress

Lee V, MacKenzie G, Hooper A, Maguire J. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus. 2016 Oct;26(10):1276-90. doi: 10.1002/hipo.22604. PubMed PMID: 27163381; PubMed Central PMCID: PMC5030140.

Hooper A, Maguire J. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus. 2016 Jan;26(1):41-53. doi: 10.1002/hipo.22487. PubMed PMID: 26135556.

MacKenzie G, Maguire J. Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res. 2015 Jan;109:13-27. doi: 10.1016/j.eplepsyres.2014.10.003. PubMed PMID: 25524838; PubMed Central PMCID: PMC4272449.

Lee V, Sarkar J, Maguire J. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology. 2014 Mar;41:75-88. doi: 10.1016/j.psyneuen.2013.12.011. PubMed PMID: 24495609; PubMed Central PMCID: PMC3947777.

Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 2011 Dec 14;31(50):18198-210. doi: 10.1523/JNEUROSCI.2560-11.2011. PubMed PMID: 22171026; PubMed Central PMCID: PMC3272883.